Bioactive Small Molecules
Medchemexpress LLC HY-N2083 5mg Medchemexpress, Handelin CAS:62687-22-3 Purity:>98%
Medchemexpress, HY-N2083 5mg Handelin CAS:62687-22-3 Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC ARMET/MANF Human H 500ug
Recombinant human mesencephalic astrocyte-derived neurotrophic factor (MANF) supplied lyophilized with an N-terminal His tag. The product corresponds to UniProt P55145 (residues L25-L182), is expressed in E. coli, and is provided at high purity for research applications including studies of neuroprotection, endoplasmic reticulum stress, and cell signaling.
- His-tagged for affinity purification and detection.
- Expressed in E. coli for efficient production.
- Contains residues L25-L182 of the human sequence.
- Purity ≥95% as determined by reducing SDS-PAGE.
- Do not reconstitute below 100 μg/mL in ddH2O.
- Lyophilized for long-term storage; aliquot and freeze for extended stability.
- Suitable for in vitro research on neuroprotection and ER stress pathways.
Medchemexpress LLC (E)-Akt inhibitor-IV | 959841-49-7 | 98.6% | 614.54 | 1 ML
(E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor with potent cytotoxic properties. It is intended for research use only and is not sold to patients.
- Acts as a PI3K-Akt inhibitor
- Exhibits potent cytotoxic properties
- Shows an average GI20 of 0.04 μM on four cell lines including MDA-MB468, MDA-MB231, MCF7, and 184B5 cells
- Has little effect on the growth of 184B5 non-cancer cells at average GI20 doses
AdipoGen Compound 34 (200 µg)
Chemical. CAS: 564462-36-8. Formula: C31H24F3N3O3. MW: 543.5. Cell permeable, highly potent inhibitor of gamma-secretase (IC50 = 0.06 nM).
Cayman Chemical ANTIBODY Tezacaftr 10mg
An investigational compound that promotes the maturation of Delta F508 mutants of CFTR
Cayman Chemical ANTIBODY SU 16f 5mg
A potent inhibitor of PDGFRβ (IC50 = 10 nM); inhibits VEGFR2 (IC50 = 140 nM); selectively inhibits PDGF- over VEFG-, FGF-, and EGF-induced cell proliferation (IC50s = 0.11, 10, 10, and 21.9 μM, respectively); accelerates downregulation of fibroblast genes and increases the yield of beating clusters in HFFs treated with 15 compounds to induce a cardiac myocyte-like phenotype
Medchemexpress LLC (±)-Vesamicol hydrochloride | 120447-62-3 | 99.8% | 25 MG
(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. It also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively. The pharmacological actions of (±)-Vesamicol are attributed to the inhibition of acetylcholine transport into synaptic vesicles and subsequent quantal release of acetylcholine.
- Potent vesicular acetylcholine transport inhibitor
- Displays high affinity for σ1 and σ2 receptors
- Inhibits acetylcholine transport into synaptic vesicles
- Reduces subsequent quantal release of acetylcholine
- Increases cytosolic acetylcholine levels in rat brain
- Decreases vesicular acetylcholine levels in rat brain (except striatum)
Selleck Chemical LLC Sodium L-lactate
Sodium L-lactate is used as a food additive preservative acidity regulator and bulking agent
STEMCELL Technologies SCR7, Size: 5 mg
SCR7 is an inhibitor of DNA ligase IV, which is responsible for the repair of DNA double-strandbreaks via the non-homologous end joining (NHEJ) repair pathway (Srivastava et al.). Due to its reported success in impeding cancer cell growth and potential impact on future cancer therapeutics, SCR7 has been closely studied in many recent publications (Hosoya & Miyagawa; John et al.). GENOME EDITING·Inhibits NHEJ-dependent DNA repair; this inhibition is reported to enhance precise homology-directed repair (HDR)-dependent CRISPR-Cas9 genome editing (Chu et al.; Maruyama et al.; Pinder et al.). However, these effects are cell type-specific and context-dependent (Song et al.; Xie et al.; Yang et al.; Zhang et al.).CANCER RESEARCH·Activates apoptosis of cancer cells by inhibiting DNA ligase IV to increase the efficacy of DNA double-strand break-inducing therapy (chemo- or radio-therapy) (Srivastava et al.).
Medchemexpress LLC Endo CNTinh-03 | 345288-49-5 | 427.51 | 5 MG
Endo CNTinh-03 is an inhibitor designed to prevent the elevation of cyclic AMP (cAMP) and cyclic GMP (cGMP) that are typically induced by agonists like G protein-coupled receptors, adenylate cyclase, and guanylate cyclase.
- Inhibits cholera toxin-induced CFTR chloride current
- Inhibits Escherichia coli (STa) toxin-induced CFTR chloride current
- Ameliorates secretory diarrhea in mouse models
- Prevents cyst growth in polycystic kidney disease models
- Exhibits an IC50 of 4 μM against the elevation of cAMP and cGMP
Apexbio Technology LLC Go 6976, 25mg Cas# 136194-77-9
Go 6976 5mg. Go 6976 is a selective inhibitor of PKC with IC50 value of 20 nM [1] [2]. There are other sizes available. Please inqury us for quote.
Apexbio Technology LLC SL-327, 5mg. Cas: 305350-87-2 MFCD: MFCD06411432. Selective MEK1/2 inhibitor
SL-327 is a selective inhibitor of MEK1 and MEK2 with IC50 values of 0.18 and 0.22M, respectively.MEK1 and MEK2 (ERK) are a kinase enzyme which phosphorylate mitogen-activated protein kinase (MAPK). Other sizes are available. Please inqury us for quote.
Medchemexpress LLC (Rac)-TBAJ-876 | 2131784-39-7 | 99.98% | 25 MG
- Racemate of TBAJ-876
- Inhibits *Mycobacterium tuberculosis*
- Analogue of Bedaquiline (HY-14881)
- Suitable for tuberculosis research
Cayman Chemical RemoxIprIdehydrochlorIde 5mg
An atypical antipsychotic and dopamine D2 receptor antagonist (Ki = 0.2 µM); selective for the D2 receptor over a panel of 33 receptors, neurotransmitter transporters, and ion channels at 10 µM but does inhibit the σ receptor (Ki = 0.065 µM); increases striatal DOPAC and HVA levels in rats from 2-20 µmol/kg; inhibits apomorphine-induced stereotypy and hyperactivity in rats (ED50s = 5.6 and 0.8 µmol/kg, respectively)
Selleck Chemical LLC Smilagenin E5001-5MG
Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density Smilagenin (SMI) attenuates A (25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor may represents a novel therapeutic strategy for AD