Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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5,971 – 5,985 of 60,541 results

5,971

Cayman Chemical 4-hydroxy MET, Purity: ≥98%, CAS: 77872-41-4, 5 mg

An analytical reference standard categorized as a tryptamine; induces the HTR in mice; intended for research and forensic applications

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5,972

Apexbio Technology LLC Hydroxyzine 2HCl, 500mg Cas# 2192-20-3

Hydroxyzine is a histamine H1-receptor antagonist, inhibits binding of [³ H]pyrilamine/[³ H]desloratadine to human histamine H1 receptor with IC50 of 10 nM/19 nM. 2192-20-3. MFCD00058200 Hydroxyzine is a histamine H1-receptor antagonist, inhibits binding of [3H]pyrilamine/[3H]desloratadine to human histamine H1 receptor with IC50 of 10 nM/19 nM. There are other sizes available. Please inqury us for quote.

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5,973

Selleck Chemical LLC NADP E7274-50MG

NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism which is alternately oxidized (NADP ) and reduced (NADPH) and can maintain cellular redox homeostasis and regulate many biological events including cellular metabolism NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance NADPH plays a multifunctional role in regulating inflammation redox homeostasis and synthetic metabolism processes

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5,974

Medchemexpress LLC Hydrocortisone 21-hemisuccinate sodium | 125-04-2 | 99.7% | 100 MG

Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid that inhibits proinflammatory cytokine activity, with IC50s of 6.7 μM for IL-6 and 21.4 μM for IL-3. This compound can be used for the research of ulcerative colitis (UC).

Orally active physiological glucocorticoid
Inhibits proinflammatory cytokine activity (IL-6 and IL-3)
Can be used for research of ulcerative colitis (UC)
Reduces weight loss and increases food intake in mice at 30 mg/kg dosage
Significantly decreased disease activity index (DAI) scores and myeloperoxidase (MPO) activity in a rat model of colitis

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5,975

Cayman Chemical Boldenone Undecylenate, Purity: ≥98%, CAS: 13103-34-9, 5 mg

An analytical reference standard categorized as an anabolic androgenic steroid; has been used to enhance physical performance in racehorses and athletes; intended for research and forensic applications

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5,976

Cayman Chemical (+)-Borneol, Purity: ≥95%, CAS: 464-43-7, 500 mg

A bicyclic monoterpene with diverse biological activities; a positive allosteric modulator of α1β2γ2L subunit-containing GABAA receptors (EC50 = 248 μM for human recombinant receptors); dose-dependently increases the paw withdrawal threshold following segmental spinal nerve ligation surgery or intraplantar injection of CFA in mouse paw; inhibits increases in ROS levels and cytotoxicity at 100 μM in SH-SY5Y neuroblastoma cells incubated with Aβ42; inhibits the growth of Gram-positive and Gram-negative bacteria in vitro, including E. coli, S. aureus, P. aeruginosa, P. vulgaris, and S. typhimurium (MICs = 125-250 μg/mL)

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5,977

AdipoGen 3-Guanidinopropionic acid (1 g)

Chemical. CAS: 353-09-3. Formula: C4H9N3O2. MW: 131.1. Synthetic. Competitive creatine uptake inhibitor. Creatine analog that alters skeletal muscle energy expenditure. Thermogenesis inhibitor. Inhibitor of energy expenditure through reduction of ATP. AMPK stimulator and PGC-1alpha activator. Reduces cellular ATP, creatine and phosphocreatine levels, consequently stimulating AMP-activated protein kinase (AMPK) and activating PPARgamma coactivator 1alpha (PGC-1alpha). Evokes a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake and increased fatigue tolerance. Ameliorates hyperglycemia in animal models of non-insulin-dependent diabetes (NIDDM). Improved insulin sensitivity and promoted weight loss selectively from adipose tissue. Studied for potential use during protein refolding as an anti-aggregatory molecule similar to L-arginine.

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5,978

Medchemexpress LLC Iso-VQA-ACC (acetate) | 99.48% | 625.63 (free base) | 10 MG

Iso-VQA-ACC acetate is a substrate for constitutive proteasome, designed for research applications. This compound is provided as a white to off-white solid with a high purity of 99.48% and a molecular weight of 625.63 (free base).

Substrate for constitutive proteasome
Molecular formula: C29H35N7O9.xC2H4O2
Sequence: iso-Val-Gln-Ala-{ACC}
Target: Proteasome
Pathway: Metabolic Enzyme/Protease
Powder storage: -80°C for 2 years, -20°C for 1 year (sealed, away from moisture)
In solvent storage: -80°C for 6 months, -20°C for 1 month (sealed, away from moisture)
Solubility: 100 mg/mL in DMSO (ultrasonic assistance)
Appearance: White to off-white solid

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5,979

eMolecules 1609402-14-3 | HA15 | Medchem Express | MFCD30377202 | 466.57 | C23H22N4O3S2 | 98 | CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc1cccc(c1)-c1csc(NC(C)=O)n1 | 5mg | 446255469

Medchem Express | BTK inhibitor 10 | 5mg | 769193291 | HY-125997 | 2241732-30-7 | 441.491 | C25H23N5O3

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5,980

Cayman Chemical Acitretin, Purity: ≥98%, CAS: 55079-83-9, 100 mg

A retinoid and an active metabolite of the retinoid etretinate that has antiproliferative activities; binds to CRABP-1 and CRABP-II (Kds = 3 and 15 nM, respectively, for the mouse recombinant proteins) but has low affinity for human recombinant retinoic acid receptor-retinoid X receptor (RAR-RXR) heterocomplexes; inhibits proliferation (IC50 = 6.6 µM) and suppresses TNF-α- and IFN-γ-induced protein levels of STAT1, NF-ĸB, and RANTES in HaCaT keratinocytes when used at 50 µM; inhibits proliferation of HL-60, SCC4, SCC15, and A431, but not MCF-7, cancer cells, at 30 µM; decreases the severity of psoriatic-like skin lesions in K14-VEGF transgenic mice (20 µg per mouse)

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5,981

Cayman Chemical 1-Stearoyl-3-Linoleoyl-rac-glycerol, Purity: ≥98%, CAS: 126301-96-0, 5 mg

A diacylglycerol; levels increase in a time-dependent manner during ripening of dry-cured sausages

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5,982

STEMCELL Technologies Cytochalasin D

Inhibits actin polymerization - 5 Mg

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5,983

Selleck Chemical LLC Bosutinib S1014-200MG

Bosutinib is a novel dual Src/Abl inhibitor with IC50 of 1 2 nM and 1 nM in cell-free assays respectively Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK p-S6 and p-STAT3 Bosutinib promotes autophagy

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5,984

Selleck Chemical LLC Telisotuzumab vedotin-1MG-5

Telisotuzumab vedotin (Teliso-V ABBV-399) is an antibody-drug conjugate (ADC) composed of the anti c-Met humanized monoclonal antibody coupled to the cytotoxic monomethyl auristatin E (MMAE) through a mc-val-cit-PABC type linker Telisotuzumab vedotin can be used for research on advanced solid tumours

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5,985

AdipoGen Hydroxyectoine

Natural chemical product. CAS 165542-15-4. Formula C6H10N2O3. MW 158.2. Isolated from halophilic bacteria Halomonas elongata. The ectoines belong to the class of compatible solutes also called extremolytes osmolytes from extremophiles. Extremolytes stabilize biological structures and macromolecules such as lipid membranes and proteins against a variety of stress factors, including high temperature, freeze-thaw cycles, drying and degradation. These very stable, non-toxic, animal-free protective agents are powerful additives in various Life Science applications, ranging from cryoprotection of animal cells over protein storage to PCR. They are protective osmolytes selected by nature for stabilization of all proteins in the cell against denaturing environmental stress without altering their functional activity. The stabilizing effect is based on the fact, that the protective osmolytes are strong water-structure formers and as such are preferentially excluded from the protein surface.

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Medchemexpress LLC Hydrocortisone 21-hemisuccinate sodium | 125-04-2 | 99.7% | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Iso-VQA-ACC (acetate) | 99.48% | 625.63 (free base) | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Hydrocortisone 21-hemisuccinate sodium | 125-04-2 | 99.7% | 100 MG

Medchemexpress LLC Iso-VQA-ACC (acetate) | 99.48% | 625.63 (free base) | 10 MG